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Accession Number:
ADA247960
Title:
Use of Synthetic Peptides and Anti-Idiotypes for Controlling Human Immunodeficiency Virus Infection
Descriptive Note:
Annual rept. 1 Aug 1990-31 Jul 1991
Corporate Author:
SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH SAN ANTONIO TX
Report Date:
1991-08-30
Pagination or Media Count:
11.0
Abstract:
This annual report describes our research effort in examining the use of synthetic peptides and anti-idiotypes anti-Id as two strategies for controlling human immunodeficiency virus HIV type 1 HIV-1. Utilizing synthetic peptides to define Linear epitopes on HIV-1 gp160, we compared the fine specificity of the humoral immune response to HIV-1 infection in humans representing two geographically diverse populations. In addition, we examined the anti-gp160 fine specificity in HIV-1 infected chimpanzees and recombinant gp160 immunized mice. We attempted to correlate reactivity to selected gp160 epitopes defined by peptides with disease progression andor in vitro neutralizing activity. Immunization studies were performed using selected synthetic peptides and novel adjuvant formulations to assess the ability to induce anti-HIV-1 gp160 responses in experimental animals. Murine monoclonal anti-Id reagents, both noninternal image and internal image in nature, were also developed and tested for the ability to induce anti-gp160 AB-3 responses in vivo. The molecular basis of monoclonal anti-ID was assessed by determining the variable V region gene sequence. These two strategies may serve to develop novel vaccination modalities andor active immunization principles for controlling HIV-1 infection in vivo.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
