Accession Number:

ADA247958

Title:

Human Immune Response to Dengue Infections

Descriptive Note:

Final rept. 1 Jul 1986-30 Jun 1991

Corporate Author:

MASSACHUSETTS UNIV MEDICAL SCHOOL WORCESTER

Personal Author(s):

• Ennis, Francis A.

Report Date:

1991-06-30

Pagination or Media Count:

83.0

Abstract:

The purpose of this contract was to analyze human immune responses to dengue virus infections. To understand the role of immune responses in recovery from dengue virus infection and in the pathogenesis of dengue hemorrhagic fever and dengue shock syndrome, we have analyzed human CD4 CD8- T cell responses to dengue virus, human CD8 CD4- T cell responses to dengue viruses, activation of T lymphocytes in vivo in dengue virus infections, dengue virus infection of human cell lines, enhancement of dengue virus infection by antibodies to dengue virus, antibody-dependent enhancement of dengue virus infection mediated by bispecific antibodies, production of interferon by dengue virus infected cells, and induction of virus infected monocytes.

Descriptors:

• *INFECTIOUS DISEASES
• *DENGUE VIRUS
• ACTIVATION
• PRODUCTION
• HUMANS
• SIGNS AND SYMPTOMS
• RESPONSE
• HEMORRHAGIC FEVERS
• VIRUSES
• IN VIVO ANALYSIS
• DENGUE
• SHOCK(PATHOLOGY)
• FEVERS
• INDUCTION SYSTEMS
• PATHOGENESIS
• MONOCYTES
• IMMUNITY
• VIRUS DISEASES
• T LYMPHOCYTES
• ANTIBODIES
• RESPONSE(BIOLOGY)
• IMMUNOLOGY
• INTERFERON

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE