Accession Number:

ADA247778

Title:

Precomplexation and Activation of Carboxylate and Phosphate Esters

Descriptive Note:

Final rept. Mar 1988-Feb 1991

Corporate Author:

OHIO STATE UNIV COLUMBUS DEPT OF CHEMISTRY

Personal Author(s):

• Czarnik, Anthony W.

Report Date:

1992-03-02

Pagination or Media Count:

7.0

Abstract:

We are looking for reaction types that simultaneously provide for the reaction of acyl and phosphoryl groups under non-forcing conditions suggest ways for elaboration into catalytic cycles with turnover behavior and, survive translation onto binding moieties. To date, we have focused on artificial metalloenzymes derived from cobaltIII and copperII coordination complexes with cyclodextrins, preassociating alpha-nucleophiles, and binuclear metal ion complexes. Cyclodextrins have been prepared bearing imidazole as a group with reactivity at pH 7 pendant coordination complexes have likewise been employed. However, as potential pendant groups, alpha-nucleaophiles such as hydrazine or hydroxylamine offer unique properties.

Descriptors:

• *ESTERS
• HYDRAZINES
• CYCLES
• DEXTRINS
• PHOSPHATES
• HYDROXYL RADICALS
• AMINES
• CATALYSIS

Subject Categories:

• Inorganic Chemistry
• Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE