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The Relationship between Vasoactive Intestinal Polypeptide and Whole-Body Sweat Rate during Exercise.
Interim rept. May-Dec 90,
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
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The purpose of this study was to examine the relationship between vasoactive intestinal polypeptide VIP and sweat rate during exercise. Seven male volunteers performed one hour of exercise at 60 of their maximal oxygen uptake VO2 max in 15 degC, 25 degC, and 35 degC conditions. Vasoactive intestinal polypeptide, whole-body sweat rate, and forearm skin blood flow were measured during each condition. Sweat rate and delta VIP postexercise value minus preexercise value demonstrated a significant p 0.05 linear relationship, with r 0.73. Forearm skin blood flow and VIP were also linearly related, with r 0.46 p 0.05. These results support the hypothesis that active cutaneous vasodilation and sweat rate are physiologically linked via the co-release of acetylcholine and VIP at the eccrine sweat gland. Furthermore, these findings strongly suggest that VIP plays a role in the human thermoregulatory response to exercise in the heat. Heat exercise sweat rate vasoactive intestinal peptide VIP blood flow
APPROVED FOR PUBLIC RELEASE