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The Effect of a Three-Week Adaptation to a Low Carbohydrate/High Fat Diet on Metabolism and Cognitive Performance
Final rept. Jun 1988-Jul 1989
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
Pagination or Media Count:
One of the principal metabolic adaptations to endurance training is an increase in the muscles utilization of fat. This study investigated several components of metabolism during a three-week adaptation to a low 7-9 carbohydratehigh 73-75 fat diet LCD in man. Metabolic measurement were taken initially on ten healthy male volunteers, ages 19-41, on maintenance exercise program while consuming a standard diet STD 50 carbohydrate35 fat . These measurements were subsequently repeated after 7-11 and 17-21 days on the LCD. Questionnaires were administered on repeat occasions to evaluate food acceptability and subjective symptoms. The metabolic tests included intravenous glucose tolerance tests GTT, meal response tests MRT, and glucoseinsulin clamps CLAMP. Blood samples were also taken on several occasions during the STD and LCD periods to asses changes in overnight fasted blood glucose, free fatty acids, triglycerides, insulin, glucagon, cholesterol TOTAL, HIGH DENSITY LIPOPROTEIN HDL, low density lipoprotein LDL, cortisol, thyroid hormone, electrolytes, ketone bodies. The LCD was well-tolerated during the three-week adaptation period. The LCD produced lower blood triglycerides -30, glucose, thyroid hormone, and insulinglucagon ratio. The LCD also elevated blood HDL- cholesterol, free fatty acids, and transiently elevated cortisol and beta-OH- butyrate. The MRT demonstrated markedly lower insulin, glucose, and triglyceride concentrations from consuming the LCD. The metabolic adaptation to the LCD resulted in unchanged insulin response to the GTT in the face of higher blood glucose during the test. Diet, Metabolism, Triglycerides, Insulin, Glucose tolerance, Low carbohydrate, Cholesterol.
APPROVED FOR PUBLIC RELEASE