Accession Number:

ADA247531

Title:

Indeterminate HIV-1 Western Blots: Etiology, Natural History and Psychological Reactions

Descriptive Note:

Rept. for 17 Aug 1990-16 Aug 1991

Corporate Author:

WASHINGTON UNIV SEATTLE SCHOOL OF MEDICINE

Personal Author(s):

• Celum, Connie
• Inui, Thomas

Report Date:

1991-09-24

Pagination or Media Count:

88.0

Abstract:

236 PERSONS CASES WITH PAST REACTIVE HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 HIV-1 EIAS and indeterminate HIV-1 Western Blots IWBS were followed prospectively. Of the 159 cases followed 6 months, 6 seroconverted 3.8 seroconversation risk. All 6 seroconverters reported HIV risk behaviors, all had p24 bands prior to seroconversion, and 5 of the 6 seroconverted within one month. HIV-1 culture, polymerase chain reaction, serum p24 antigen, and the recombinant assays, CBre 3 and Syva Microtrak, had specificities of 100, 99.1, 100, 97.1, and 100, respectively. An algorithm for evaluation of persons with IWB is proposed. A case-control study demonstrated past positive tuberculin skin test, recent tetanus booster, autoantibodies, and parity were associated with IWBs. No cross-reactivity was seen with HTLV-1 or HIV-2. Cases reported significantly more anxiety than controls, due in large part to the IWB. High- risk cases reported more anxiety than low-risk cases. Informational brochures for counseling were designed.

Descriptors:

• *MEDICINE
• *HUMAN IMMUNODEFICIENCY VIRUSES
• *ANTIGENS
• ALGORITHMS
• RISK
• HUMANS
• REACTIVITIES
• PARITY
• CULTURES(BIOLOGY)
• CHAIN REACTIONS
• TETANUS
• ANXIETY
• COUNSELING
• SKIN TESTS
• TUBERCULIN

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE