Accession Number:

ADA245430

Title:

Evaluation and Management of Patients with Inhalation Injury

Descriptive Note:

Corporate Author:

ARMY INST OF SURGICAL RESEARCH FORT SAMHOUSTON TX

Report Date:

1990-12-01

Pagination or Media Count:

7.0

Abstract:

Inhalation injury, present in approximately one third of burned patients treated at burn centers, increases mortality by a maximum of 20 in relation to age and extent of burn. The development of animal models of inhalation injury has made possible the identification of both airway and vascular responses evoked by smoke inhalation. Inflammatory occlusion of terminal bronchioles and necrosis of the endobronchial mucosa render the airway and pulmonary parenchyma susceptible to infection and the resulting pneumonitis further increases mortality. Early diagnosis, best achieved by endoscopic bronchoscopy and xenon ventilation perfusion scan, permits timely application of high-frequency ventilation that appears to reduce the incidence of pneumonia and to decrease mortality. Pharmacologic agents give promise of ameliorating the deleterious changes of the vasculature. The recent advances in understanding inhalation injury have identified the research needed to further improve patient salvage.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE