Adjuvant Action of Lipopolysaccharides and Derivatives. New Aspects of the Adjuvant Action of Lipid A and Its Analogs. Conference held in Airlie, Virginia on April 6 - 9, 1991
Final proceedings rept.,
RIBI IMMUNCOCHEM RESEARCH INC HAMILTON MT
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A typical lipid A Escherichia coli type is composed of glucosamine disaccharide backbone with 1,4-bisphosphate and hexaacyl substituents at the 2, 2, 3 and 3 positions. We have synthesized lipid A analogs with monosaccharide backbone carrying phosphate and acyl substituents, and their biological activities examined. Analogs possessing monophosphate and triacyl substituents to monoglucosamine backbone were generally active. A representative analog GLA- 60, which exhibits various immunomodulating activities such as induction of mediators, activation of B cells or macrophages, enhancement of nonspecific resistance and so on, has a 3-hydroxytetradeconoyl C14-OH, a 3- tetradecanoyloxytetradecanoyl C14-O-C14 and a phosphate groups at the 2, 3 and 4 positions of a glucosamine backbone, respectively. Tolerance inducing activity against lethal toxicity of LPS was, however, observed even in such scarcely active analogs.