Accession Number:

ADA244806

Title:

Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulations as a Potential Blood Substitute

Descriptive Note:

Rept. no. 3 for period ending 1991,

Corporate Author:

OHIO STATE UNIV COLUMBUS COLL OF PHARMACY

Personal Author(s):

Report Date:

1991-11-08

Pagination or Media Count:

13.0

Abstract:

Attached are two summary sheets showing the structures of several, new LR16 analogues recently synthesized with the support of Department of the Navy Grant No. N000014-90-J-1648. Preliminary testing has shown organic compounds to be active, achieving P50 values in LEH suspensions at drug concentrations of 3 mM. Testing of the organic compounds listed on the second sheet 01 series is presently underway. The two lists of structures is followed by the experimental section outlining synthetic methodologies. The final three pages of this report summarize a synthetic scheme and nuclear magnetic resonance data concerning our first analogue which contains a quaternary, permanently charged nitrogen moiety which should significantly reduce drug leakage from liposome. We are presently testing the ability of this agent to modulate the P50 value of hemoglobin.

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE