Study of Compounds for Activity against Leishmania
Annual rept. 28 Sep 1990-27 Oct 1991,
GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
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During the period covered by this report, a total of 75 compounds were tested for efficacy against Leishmania donovani infections in hamsters. A computer analysis of the data from the study of approximately 6000 compounds tested since this project was initiated in 1974 suggested a number of compounds with sufficient promise to warrant further study during this contract period. The 8-aminoquinolines were the most active compounds studied, one of which was 100 suppressive at dosage levels as low as 13mgkg. Six phenanthrene methanols as well as two dibenzopyrroles selected for study were not highly active against L. donovani, and some were toxic.