Analysis of the Human T Cell Response to HTLV-III (AIDS)
Final rept. 1 Jul 1987-30 Jun 1990,
DANA-FARBER CANCER INST BOSTON MA
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Although patients with HIV infection have depressed T cell function, the fact that they produce antibodies to HIV proteins 1 and even have lymphocytes capable of lysing infected target cells 2 indicates the presence of an immune response to this virus. The purpose of this contract is to devise methods to characterize that T cell response in a variety of patient populations. Once the T cell response has been defined, it should be possible to attempt to augment any response which could be effective at the elimination of virus as well as potentially dampening ineffective responses, eliminating unwanted responses. We are concerned with two major issues with regard to the interaction of T cells and HIV 1 what make some T cells susceptible to virus and 2 why are some CD4 cells apparently virus resistant Therapeutic modalities ideally would preserve T cell function while specifically eliminating the spread of the virus. We have begun to investigate therapeutics with these properties with the goal of finding a safe, effective treatment.
- Medicine and Medical Research