Receptor Subtype Alterations: Bases of Neuronal Plasticity and Learning
Final technical rept.,
BOWMAN GRAY SCHOOL OF MEDICINE WINSTON-SALEM NC
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The following findings were reported 1 Oxotremorine-M binding in rabbit thalamus and cingulate cortex increased during discriminative avoidance conditioning DAC. 2 Excitatory and discriminative neuronal activity was documented throughout DAC and there were relationships between training-induced neuronal activity and changes in binding. 3 Turnover of noradrenaline was significantly elevated during DAC suggesting a role for this transmitter in long-term memory. 4 Anterior cingulate cortex lesions uncover discriminative neuronal activity in the striatum and amplify activity in thalamus. 5 The structure connections and spontaneous activity of the lateral magnocellular nucleus in thalamus were described. 6 A review was written of the structure and function of cortical layer I and its role in learning and memory analyzed. These are the first studies to document physiological regulation of receptors and transmitters that occur during avoidance learning and provide the basis for a comprehensive analysis of the molecular bases for learning and memory.
- Anatomy and Physiology