Antibody to the RNA-Dependent DNA Polymerase of HTLV-III: characterization and Clinical Associations
Annual rept. 15 Nov 88-14 Nov 89,
CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK
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The identification and characterization of anti HIV reverse transcriptase antibodies in the sera of HIV seropositive individuals, and correlation of their levels with clinical status and defects in immune function. In my Annual Report of 1987 we described the identification of a series of purified IgGs from HIV seropositive individuals capable of blocking the catalytic activity of HIV-associated reverse transcriptase. The specificity of these antibodies, lack of cross-reactivity with mammalian and prokaryotic DNA polymerases, and correlation with clinical health was described. In 1988 we had greatly expanded these studies. We prepared bulk quantities of these anti- polymerase IgGs, and these on deposit with the NIH. We began investigating the biologic activity of consensus sequences for hormone responsive elements in the HIV-LTR, as a model for the investigation of certain steroid-based compounds which may have immunomodulatory activity as well as inhibit the induction of chronic viral infection.
- Medicine and Medical Research