Neuropharmacological Characterization of Botulinum Neurotoxin
Midterm rept. 30 Mar 1990-29 Sep 1991
JEFFERSON MEDICAL COLL PHILADELPHIA PA
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The purpose of the work is to find drugs that will antagonize the actions of clostridial neurotoxins. Studies will be conducted initially on neuromuscular preparations, cells in culture, or other tissues obtained from laboratory animals. When a promising drug is identified, it will be tested as an antagonist of toxin action on human tissues. During the first half of the contract, experiments have been done to evaluate Zaprinast and other drugs that alter the levels or tissue distribution of c-GMP and its synthesizing and degrading enzymes. These substances have previously been reported to antagonize clostridial neurotoxins on a tissue culture line. The results have produced an unexpected outcome. The drugs antagonize toxins on one type of tissue preparation but not another. This unexpected finding may have important implications for understanding toxin action.
- Medicine and Medical Research