Chemoprophylaxis and Antidotal Efficacy of Alpha-Ketoglutaric Acid in Hydrogen Cyanide Poisoning
Final rept. 14 Mar 88-13 Sep 90,
MISSISSIPPI UNIV MEDICAL CENTER JACKSON
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A model to study the toxic effect for hydrogen cyanide HCN by inhalation and to evaluate the efficiencies and relative potencies of possible antidotes has been established. Several chambers and accompanying mechanics of administration of HCN were designed and evaluated. This model is especially designed to be used to study the effects of HCN at different concentrations and to evaluate the effectiveness of the antidotes with pre- and post-exposure of mice and rats to HCN. In addition, pulmonary and cardiovascular changes in the rat can be monitored. This allows more discrete determination of the efficacy of antidotes and monitoring of toxic effects other than lethality. During exposure, HCN concentrations in the chamber were continuously monitored by detector tubes, electrochemical sensor, and chemical colorimetric methods. Mice were placed in a cage which was quickly inserted and removed from the chamber. Rats were placed in a rat hold tube for insertion of nose-only exposure.
- Medicine and Medical Research