Accession Number:

ADA243549

Title:

Post-Doctoral Research Award

Descriptive Note:

Final rept.,

Corporate Author:

SOCIETY OF TOXICOLOGY WASHINGTON DC

Personal Author(s):

Report Date:

1988-12-01

Pagination or Media Count:

17.0

Abstract:

For the embryolethality tests, semicarbazide and isoniazid showed a slightly less than additive embryolethal response. Potentially different lethal modes of action may be observed for compounds that are thought to be teratogenic by the same mode of action. For the embryolethal binary mixture test of hydroxyurea and isoniazid the 31 mixture showed an antagonistic response, while the 11 and 13 mixtures were response additive, as expected. The antagonistic response may have been the result of poorer absorption of hydroxyurea by the severely malformed embryos, as isoniazid had a much greater concentration in mgL than did hydroxyurea, even though the effective lethal concentration for hydroxyurea was nearly three times that for isoniazid. Short-chain carboxylic acids showed concentration additive joint actions for induction of malformation. Combinations of DNA synthesis inhibitors showed response additive to antagonistic joint actions ay malformation-inducing concentration.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE