Presynaptic Modulation of the Hippocampal Mossy Fiber Synapse
Annual rept. 15 Sep 1990-14 Sep 1991,
EAST CAROLINA UNIV GREENVILLE NC
Pagination or Media Count:
The overall goal of this research project is to systematically investigate a number of the possible ways through which presynaptic modulation might influence the effectiveness of local synaptic interactions at the mammalian hippocampal mossy fiber synapse. A hippocampal subcellular fraction that is highly enriched in large mossy fiber nerve endings was developed for this purpose. The morphological and metabolic properties of this synaptosomal preparation have previously been described, and both glutamate and prodynorphin derived peptides have been shown to be released from these specialized nerve endings in response to membrane depolarization by calcium-dependent mechanisms. During the first year of this research project, it was demonstrated that distinct types of voltage-gated calcium channels are required for the exocytosis of glutamate and dynorphin peptides.
- Medicine and Medical Research