Immunological Approach to the Identification and Development of Vaccines to Various Toxins
Annual rept. 15 Mar 1990-14 Mar 1991
SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH SAN ANTONIO TX
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Murine monoclonal anti-saxitoxin and anti-ricin antibodies capable of protecting against the in vitro toxicity of saxitoxin and ricin, respectively, have been generated. These protective anti-toxin Ab1 antibodies are being used to induce the production of internal image monoclonal anti-idiotypic antibodies Ab2 which may serve as vaccines in the induction of active and protective immunity against these toxins. The murine responses to synthetic peptides homologous to immunogenic amino acid sequences of the ricin A and B chains have also been investigated either singly or in combination with the aim of developing a subunit vaccine against ricin in vivo toxicity.