Accession Number:

ADA243075

Title:

Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulations as a Potential Blood Substitute

Descriptive Note:

Performance rept. no. 3 for period ending 1991,

Corporate Author:

OHIO STATE UNIV COLUMBUS DIV OF PHARMACEUTICS

Personal Author(s):

Report Date:

1991-11-08

Pagination or Media Count:

13.0

Abstract:

Two summary sheets show the structures of several, new LR16 analogues recently synthesized. Preliminary testing has shown compounds 19, 22, and 25 to be active, achieving P50 values in LEH suspensions of 29.5, 28.5, and 21.0 mm Hg, respectively, at drug concentrations of 3 mM. The two lists of structures are followed by the experimental section outlining synthetic methodologies. The final three pages summarize a synthetic scheme and NMR data concerning our first analogue which contains a quaternary, permanently-charged nitrogen moiety which should significantly reduce drug leakage from liposome. We are presently testing the ability of this agent to modulate the P50 value of hemoglobin.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE