Accession Number:

ADA242981

Title:

Biological Effects of Protracted Exposure to Ionizing Radiation: Review, Analysis, and Model Development

Descriptive Note:

Technical rept. 15 Sep 1986-20 Jul 1990

Corporate Author:

PACIFIC-SIERRA RESEARCH CORP LOS ANGELES CA

Report Date:

1991-11-01

Pagination or Media Count:

281.0

Abstract:

Two basic approaches are developed to mathematically model biological responses to ionizing radiation exposure, including upper gastrointestinal UG distress nausea, vomiting, lower gastrointestinal LG distress diarrhea, fluid loss, and GI-syndrome lethality. Models are constructed to accommodate arbitrary histories of protracted exposure. Sets of coupled differential equations are employed to simulate dynamics of the biological processes involved. The modeling approaches are guided by a comprehensive review and analysis of relevant literature, including radiation-induced symptomatology, response dynamics, physiological changes, morphological changes, celltissue damage and recovery mechanisms, and existing radiobiological injury and recovery models. The upper gastrointestinal distress model UGIDM is a two-compartment toxicokinetic model to simulate radiation-induced production and clearing of humoral substances involved in triggering UG distress.

Subject Categories:

  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE