Accession Number:

ADA242809

Title:

An Experimental Brain Missile Wound: Ascertaining Pathophysiology and Evaluating Treatments to Lower Mortality and Morbidity

Descriptive Note:

Annual rept. 14 Apr 90-13 Apr 91; Final rept. 14 Apr 86-13 Apr 91,

Corporate Author:

LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS

Personal Author(s):

Report Date:

1991-06-04

Pagination or Media Count:

81.0

Abstract:

Cerebral ischemia does not occur following a brain wounding provided that ICP is 60 mmHg. Rather focal hyperperfusion occurs. Mechanical and chemical control of CBF are disturbed following brain wounding but these disturbances have wide regional variations. The missile-wounded brain may show severe CBF reductions with even a mild fall in MABP. No reflow follows cerebral ischemic occurring after frain wounding. Brain wounding is associated with decreased brain stem and hypothalamic biogenic amines especially epinephrine. This seems to be a part of a generalized stress response. Free radicals appear in the brain within minutes of brain injury.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE