Effects of Wound Bacteria on Postburn Energy Metabolism
Annual/Final rept. 15 Jul 1987-30 Jun 1990
MARSHALL UNIV HUNTINGTON WV SCHOOL OF MEDICINE
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This study examined the hypothesis that postburn hypermetabolism is initiated by bacteria andor their products in the burn wound. Resting metabolic rate RMR and core temperature Tc of rats were monitored before and after full-thickness, 30 total body surface burns. Wounds were seeded with non- virulent P. aeruginosa at the time of injury or allowed to colonize spontaneously. Seeding resulted in a reproducible, localized wound infection and a 20-40 increase in RMR for two weeks after injury. Unseeded rats experienced little or no change in RMR until the second postburn week. RMR and Tc were related, but burned nonbackteremic rats were frequently hypermetabolic without being febrile. Endotoxin released in the wound was not responsible for the increased RMR. Postburn hypermetabolism was unaffected by variations in wound inflammation, or changes in humoral or cell medicated immunity. Interleukin-1 IL-1 activity was uncovered in the serum of burned rats, but there was no relationship between IL-1 level and RMR.
- Medicine and Medical Research