Accession Number:

ADA242706

Title:

Determinants of Infectivity of Pathogens in Vector Ticks

Descriptive Note:

Annual rept. 1 May 89-30 Apr 90,

Corporate Author:

HARVARD UNIV CAMBRIDGE MA

Personal Author(s):

Report Date:

1990-11-15

Pagination or Media Count:

79.0

Abstract:

This report describes progress on research in which the main goal is to define the physiological properties of ticks that determine the infectivity of pathogens that they transmit. We determined whether female deer ticks Ixodes dammini Acari Ixodidae can be inseminated repeatedly and whether sperm from either mating take precedence in fertilizing eggs. By infesting deer with irradiated male I. dammini, the abundance of these vector ticks may effectively be reduced. The spirochetal agent of Lyme disease, Borrelia burgdorferi, disseminated from the guts of infected Ixodes dammini ticks following host attachment and appeared in slaiva before rapid engorgement commenced. This salivary route of infection appears to be the route of Lyme disease transmission in nature.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE