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Free Radicals Accelerate the Decay of Long-Term Potentiation in Field CA1 of Guinea-Pig Hippocampus
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Long-term potentiation LTP is a persistent increase in monosynaptic efficacy following a high frequency train. Because the potentiation can last for hours or even days in vivo, this electrophysiological phenomenon has been considered to be a correlate of memory and learning. The biochemical changes that underlie LTP are complex, possibly involving a number of second messenger systems. Free radicals and active oxygen compounds e.g. peroxide, superoxide and hydroxyl radicals are normally generated with cellular metabolism but are well controlled by intrinsic enzyme systems and antioxidants. Under certain pathological conditions, this delicate balance can be disrupted. Free radicals are thought to contribute to a number of diseases such as ischemic injury, aluminum toxicity, Alzheimers disease and Downs syndrome, all of which affect cognitive processes.
APPROVED FOR PUBLIC RELEASE