Accession Number:

ADA242587

Title:

Glycyl-L-Glutamine: A Dipeptide Neurotransmitter Derived from Beta- Endorphin

Descriptive Note:

Mid-Term rept. 3 Jan 1990-31 Aug 1991

Corporate Author:

MISSOURI UNIV-KANSAS CITY

Personal Author(s):

Report Date:

1991-09-01

Pagination or Media Count:

36.0

Abstract:

The objective of this research is to test the hypothesis that glycyl- L-glutamine, a dipeptide synthesized through the post-translational processing of Beta-endorphin, acts as a neurotransmitter in brain and a circulating hormone in the periphery. To test this hypothesis, we established three working objectives 1 to evaluate the physiological responses produced by glycyl L glutamine and test whether it modulates the opiate actions of Beta-endorphin 2 to examine its distribution in brain and pituitary and determine whether it is specifically co-localized with Beta-endorphin 3 to characterize the receptors which mediate glycyl L glutamines pharmacologic effects. During the current project period, we found that glycyl L glutamine produces three markedly different pharmacologic responses it stimulates a trophic response in cardiac myocytes, inducing expression of the asymmetric form of acetylcholinesterase, a classical marker for synaptic innervation it produces neuroimmune regulatory effects in T lymphocytes, enhancing c-myc oncogene expression.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE