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The Effects of Pralidoxime, Atropine, and Pyridostigmine on Thermoregulation and Work Tolerance in the Patas Monkey

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Final rept. Jan 89-Dec 90,

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A continuous flow indirect calorimetry system was used to continuously measure metabolic rates in patas monkeys at rest or during exercise when exposed to ambient temperatures of 25 or 35 C. The exercise system was also used to evaluate the effects of pralidoxime, atropine, andor pyridostigmine on the exercise tolerance time in primates. Rectal temperature and heart rate were continuously monitored by a telemetry system while total evaporative water loss was estimated from weight differences before and after exercise. Resting metabolic rates measured at 35 C were significantly higher than at 25 C and averaged 73.3 and 49.1 W.m2 respectively. No significant difference was observed in the exercising metabolic rates of the patas monkey measured at 25 C which averaged 126.3 and that at 35 C which averaged 123.4 Wm2. No significant drug effects on metabolic rate or respiratory quotient were observed. Pyridostigmine treatment was associated with an increase in exercise time, a lower rectal temperature, heart rate, and a 40 increase in water loss. Atropine treatment produced a decrease in exercise time of 61 min and water loss, and an increase in heart rate. Pralidoximine treatment alone or in combination with atropine had no significant effect on exercise time or thermoregulation. Pyridostigmine treatment in combination with atropine resulted in a significant increase in exercise time and a 47 increase in water loss when compared to atropine treatment alone.

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  • Medicine and Medical Research

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