Accession Number:

ADA242529

Title:

Development of a Therapeutic Agent for Wound-Healing Enhancement

Descriptive Note:

Quarterly rept. no. 2,

Corporate Author:

SRI INTERNATIONAL MENLO PARK CA

Personal Author(s):

Report Date:

1991-09-01

Pagination or Media Count:

10.0

Abstract:

During this quarter we synthesized and purified three peptides, one from PDGF A-chain sequence and two from PDGF B-chain sequence. During this quarter we conducted cell binding experiments and assays for mitogenesis. Competitive receptor binding assays were performed on four peptides using NIH 3T3 cells. None of the peptides tested so far showed any binding. We tested two peptides at three doses and two at four doses. In the future, we will test peptides initially at three doses. Active peptides will be tested at four or more doses.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE