Accession Number:

ADA242202

Title:

The 3D Structure of Some Diarrheal Causing Bacterial Toxins

Descriptive Note:

Annual rept. 1 Jul 1990-30 Jun 1991

Corporate Author:

VETERANS ADMINISTRATION MEDICAL CENTER PITTSBURGH PA

Personal Author(s):

Report Date:

1991-07-01

Pagination or Media Count:

7.0

Abstract:

The urgency to know the 3D structure of SEB is intensifying since there is a widespread effort currently to understand the mechanisms of its biological actions and of those of related staphylococcal enterotoxins SEs, especially its toxicity and its extraordinary immunogenic activity, i.e., its superantigenicity. With respect to its role as a superantigen, certain amino acid residues in SEB have been demonstrated to be essential for interaction with the V beta T cell receptor while others have been shown to be crucial for binding with the MCH-II molecule, but the spatial relationships of these important functional residues remain unknown. The information will be evident in the 3D structure. The residues which target the V beta receptor are thought to be located close to each other on the protein surface although they occur in different parts of the amino acid sequence. The same investigators find that the MHC binding regions of SEB lie in the interior of the molecule. The protein accordingly is believed to undergo a change its conformation before it is able to bind to the MHC-II molecule.

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE