Accession Number:

ADA239847

Title:

Evaluation of the Dermal Toxicity of LP1846.

Descriptive Note:

Final rept.,

Corporate Author:

BATTELLE MEMORIAL INST RICHLAND WA PACIFIC NORTHWEST LABS

Report Date:

1989-09-01

Pagination or Media Count:

41.0

Abstract:

Undiluted Liquid Gun Propellant LPG was applied directly to the unabraded skin of two swine using a saturated cotton sponge. Approximately 15 of the skin surface area was covered. Two other swine had a section of battle- dress uniform fabric soaked in LPG applied to their skin for 24 hours. A second dose of LPG was applied to all the animals 24 hours after the first dose. Pigs, both the ones receiving direct application and those treated with LPG impregnated fabric, were listless and had pale mucous membranes at the end of the first 24-hour exposure period. The skin was moderately erythematous with distinct areas of edema and eruption. By eight hours after the second application, the animals were moribund, cyanotic, tachypneic and vomiting. Blood samples were collected and the animals sacrificed at that time. Gross necropsy showed erythema, edema and subcutaneous hemorrhage in the test areas. Gastric ulceration and hemorrhage, hemorrhage in large and small intestine, and a light brown discoloration of the lungs were also noted. Methemoglobin levels increased as early as two hours after the first exposure continued to rise until about eight hours postexposure. Heinz body incidence in red cells reached nearly 100 within 16 hours of the first exposure and remained at that level until the animals were sacrificed. Studies were performed to determine the genotoxicity of LPG in the CHOHGPRT Forward Mutation Assay.

Subject Categories:

  • Toxicology
  • Ammunition and Explosives

Distribution Statement:

APPROVED FOR PUBLIC RELEASE