Accession Number:

ADA239654

Title:

Adaptation and Study of AIDS Viruses in Animal and Cell Culture Systems

Descriptive Note:

Final rept. 30 Dec 87-29 Mar 91,

Corporate Author:

VANDERBILT UNIV NASHVILLE TN SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1991-06-28

Pagination or Media Count:

76.0

Abstract:

Small animal models of HIV infection are needed to investigate various fundamental and clinical aspects of HIV disease, i.e. host immune response, viral pathogenesis, and potential interventive therapies. Several classical and novel murine models are currently being studied for these purposes, but no one ideal model has been fully characterized. Within this report, we describe an additional murine model of HIV disease which uses sublethal gamma irradiated nude mice xenotransplanted HIV permissive CEM cells to serve as a nucleus of virus replication. Nude mice are transplanted with either 1X10HIV chronically infected or naive CEM cells and monitored for tumor progression and total body weight gain over time.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE