Accession Number:

ADA239486

Title:

Comparative Mutagenicity of Urinary Metabolites of Nitropolycylic Aromatic Hydrocarbons 1-Nitropyrene, 2-Nitrofluoranthene, and 3- Nitrofluoranthene

Descriptive Note:

Master's thesis

Corporate Author:

AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING

Personal Author(s):

Report Date:

1991-01-01

Pagination or Media Count:

92.0

Abstract:

This study compared the mutagenicity of urinary metabolites of prevalent air pollutants nitropyrene, nitrofluoranthene, and nitrofluoranthene. Rats were injected intraperitoneally with specific doses and their urine was analyzed for mutagenicity by an Ames plate incorporation assay using Salmonella Typhimurium. Resulting data yielded revertant excretion rate plots used for comparative analysis. To achieve maximum mutagenicity, 1-NPs urinary metabolites required exogenous activation by S9, 2-NFAs did not vary significantly with S9 activation, while 3-NFAs was decreased by S9 metabolism. 2-NFAs mutagenic metabolites revertant excretion rate was a quarter of the rates of 3-NFAs and 1-NPs mutagenic metabolites. The strongest mutagenicity of urinary metabolites during the 48 hrs after injection was from 1-NP which was double the amounts from 3-NFA and 2-NFA.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE