Accession Number:

ADA239442

Title:

Muramyl Peptide-Enhanced Sleep: Pharmacological Optimization of Performance

Descriptive Note:

Annual rept. 1 Jun 90-31 May 91,

Corporate Author:

TENNESSEE UNIV MEMPHIS

Personal Author(s):

Report Date:

1991-06-01

Pagination or Media Count:

111.0

Abstract:

It is now recognized that sleep results from neuronal activity which is regulated by the interactions of neurons with substances produced by neurons and other cellular components of the brain. Over the past 30 years, our technical abilities to identify and synthesize biochemicals has greatly improved these advances have led to the identification of several endogenous sleep factors SFs substances that promote sleep. Over the past five years of this contract, we have identified several new SFs and synthesized analogs that may be developed into new, more effective, and safer somnogenic agents. The broad goal of this USAMRDC-supported work has been to develop the information needed to determine if it is reasonable to propose either endogenous SFs or synthetic analogs as potential sleep-inducing agents for military use.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE