Accession Number:

ADA239281

Title:

Anti-Cyanide Drugs

Descriptive Note:

Annual rept. 1 Apr 1989-31 Mar 1990

Corporate Author:

HOWARD UNIV WASHINGTON DC DEPT OF CHEMISTRY

Personal Author(s):

Report Date:

1991-06-01

Pagination or Media Count:

21.0

Abstract:

This report describes our efforts to develop anti-cyanide drugs using simple, water soluble metalloporphyrin molecules. Vanadium 4, chromium 3 molybdenum 5, manganese 3, iron 3, nickel 2, copper 2, silver 3, zinc, indium 3, aluminum, platinum 2, palladium 2, and gold 3 porphyrins had no affinity for cyanide at ph7.2. In vitro work showed cobalt 3, rhodium 3, and ruthenium 2 porphyrins bind cyanide in both the di- and trivalent states, from kinetic, equilibrium and electrochemical studies. Nickel 2 central N-alkyl porphyrins liberate nickel to complex with cyanide and are otherwise stable to nickel loss. sterically hindered porphyrins in the iron III form rapidly complex cyanide. The LD-50s of thirteen porphyrins and phthalocyanines are in the 100-600 mgkg range in rats. None of the cobalt, iron, rhodium or silver porphyrins or phthalocyanines protect mice in a prophylactic fashion against 2 LD-50s of cyanide.

Subject Categories:

  • Pharmacology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE