Antisense Oligodeoxynucleotide Inhibition of HIV Gene Expression
Final rept. 30 Sep 1986-31 Dec 1988
UNIVERSITY OF SOUTH FLORIDA TAMPA
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The goal of this work is to develop novel, efficacious, injectable, gene-specific therapeutics for treatment of human immunodeficiency virus HIV infection. These products will be nuclease resistant, stereospecific antisense inhibitors of human immunodeficiency virus gene expression and activity. Antisense DNA inhibition has worked in this laboratory against several human and viral genes in cell culture. In this project, routes are being developed for the stereospecific synthesis and purification of all-S or all-R oligodeoxynucleoside methylphosphonates directed against specific HIV mRNAs, and against tat protein. Several dimers have been prepared by the pentavalent solution route, and encouraging results have been obtained for the trivalent solution route.
- Medicine and Medical Research