Accession Number:

ADA239046

Title:

Laser Induced Retinal Injuries

Descriptive Note:

Final rept. 30 Sep 1987-30 Sep 1990

Corporate Author:

TEL-AVIV UNIV (ISRAEL)

Personal Author(s):

Report Date:

1991-07-01

Pagination or Media Count:

41.0

Abstract:

In our previous study we have shown that the ocular response to laser induced ocular injury is characterized by an inflammatory reaction with enhancement in prostaglandin PG production and a cellular infiltration. Steroid treatment curtailed the PGs response but did not effect the inflammatory infiltrate. In the present study, we investigated the involvement of leukotrienes B4 LTB4 in laser induced retinal injury. The following parameters were studied LTB4 production by the retinachoroid, its accumulation in the vitreous, and changes in vitreal protein levels.. In addition, the effect of an antileukotriene drug NDGA on LTB4 accumulation in the vitreous was studied. Histopathological evaluation of the inflammatory response following NDGA treatment alone or combined with steroids was performed well. The antileukotriene drug that has been chosen for the present study was norguaiaretic acid.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE