Accession Number:

ADA238989

Title:

The Screening and Evaluation of Experimental Antiparasitic Drugs

Descriptive Note:

Annual rept. 1 Feb 89-31 May 90; Final rept. 1 Oct 81-31 May 90,

Corporate Author:

MIAMI UNIV FL

Personal Author(s):

Report Date:

1990-09-27

Pagination or Media Count:

36.0

Abstract:

Malaria chemotherapeutic studies in mice included 6 different testing systems. A primary antimalarial blood schizonticidal test MM where in 10 years 20,500 compounds were evaluated against Plasmodium berghei with 2,100 exhibiting antimalarial activity. A casual prophylactic test RP to detect compounds active against the tissue schizonts where in 5 years over 600 compounds were tested with 380 active. A secondary antimalarial test Ag were in 10 years over 2000 compounds were evaluated in a variety of different protocols. Compounds were tested for cross resistance patterns against a battery of drug-resistant parasites. New lines resistant to mefloquine and halofantrine were developed.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE