Oral Ofloxacin Therapy of Pseudomonas aeruginosa Sepsis in Mice after Irradiation
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Death subsequent to whole-body irradiation is associated with gram- negative bacterial sepsis. The effect of oral therapy with the new quinolone ofloxacin for orally acquired Pseudomonas aeruginosa infection was tested in B6D2F1 mice exposed to 7.0 Gy of bilateral radiation from Co. A dose of 10 to the 7th power organisms was given orally 2 days after irradiation, and therapy was started 1 day later. Only 4 of 20 untreated mice 20 survived for at least 30 days compared wit 19 of 20 mice 95 treated with ofloxacin. P. aeruginosa was Ofloxacin reduced colonization of the ileum by P. aeruginosa 24 of 28 untreated mice 86 harbored the organisms, compared with only 5 of 30 17 wit ofloxacin. This experiment was replicated twice, and similar results were obtained. These data illustrate the efficacy of the quinolone ofloxacin for oral therapy of orally acquired P. aeruginosa infection in irradiated hosts.
- Medicine and Medical Research