Accession Number:

ADA238944

Title:

Administration of Interleukin-6 Stimulates Multilineage Hematopoiesis and Accelerates Recovery from Radiation-Induced Hematopoietic Depression

Descriptive Note:

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Report Date:

1991-02-01

Pagination or Media Count:

10.0

Abstract:

Hematopoietic depression and subsequent susceptibility to potentially lethal opportunistic infections are well-documented phenomena following radiotherapy. Methods to therapeutically mitigate radiation-induced myelosuppression could offer great clinical value. In vivo studies in our laboratory have demonstrated that interleukin-6 lL-6 stimulates pluripotent hematopoietic stem cell CFU-s, granulocyte-macrophage progenitor cell GM-CFC , and erythroid progenitor cell CFU-e proliferation in normal mice. Based on these results, the ability of lL-6 to stimulate hematopoietic regeneration following radiation-induced hematopoietic injury was also evaluated.

Subject Categories:

  • Psychology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE