Administration of Interleukin-6 Stimulates Multilineage Hematopoiesis and Accelerates Recovery from Radiation-Induced Hematopoietic Depression
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Hematopoietic depression and subsequent susceptibility to potentially lethal opportunistic infections are well-documented phenomena following radiotherapy. Methods to therapeutically mitigate radiation-induced myelosuppression could offer great clinical value. In vivo studies in our laboratory have demonstrated that interleukin-6 lL-6 stimulates pluripotent hematopoietic stem cell CFU-s, granulocyte-macrophage progenitor cell GM-CFC , and erythroid progenitor cell CFU-e proliferation in normal mice. Based on these results, the ability of lL-6 to stimulate hematopoietic regeneration following radiation-induced hematopoietic injury was also evaluated.