Studies of Epstein-Barr Virus Infection and Immunoregulation in Patients with Aids and Aids-Related Disorders
FOOD AND DRUG ADMINISTRATION BETHESDA MD
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The goal of this research effort was to identify the mechanisms responsible for growth of EBV-immortalized B cells and their immune regulation in vivo. In addition, this research sought to define defects of growth and regulation in EBV-infected B cells during HIV infection. Major findings include 1 identification of two molecules, IL-6 and lactic acid, responsible for autocrine growth stimulation of EBV-immortalized B cells 2 recognition of a novel regulatory mechanism responsible for growth regulation of EBV-immortalized B cells where T cells deplete growth factors required by EBV-immortalized B cells for growth and 3 identification of abnormal serum IL-6 concentrations in HIV-infected individuals and demonstration of IL-6 tumorigenicity for EBV- immortalized B cells.
- Medicine and Medical Research