Accession Number:

ADA238805

Title:

Studies of Epstein-Barr Virus Infection and Immunoregulation in Patients with Aids and Aids-Related Disorders

Descriptive Note:

Final rept.,

Corporate Author:

FOOD AND DRUG ADMINISTRATION BETHESDA MD

Personal Author(s):

Report Date:

1991-05-02

Pagination or Media Count:

56.0

Abstract:

The goal of this research effort was to identify the mechanisms responsible for growth of EBV-immortalized B cells and their immune regulation in vivo. In addition, this research sought to define defects of growth and regulation in EBV-infected B cells during HIV infection. Major findings include 1 identification of two molecules, IL-6 and lactic acid, responsible for autocrine growth stimulation of EBV-immortalized B cells 2 recognition of a novel regulatory mechanism responsible for growth regulation of EBV-immortalized B cells where T cells deplete growth factors required by EBV-immortalized B cells for growth and 3 identification of abnormal serum IL-6 concentrations in HIV-infected individuals and demonstration of IL-6 tumorigenicity for EBV- immortalized B cells.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE