Accession Number:

ADA238768

Title:

Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis

Descriptive Note:

Annual rept. no. 3, 15 May 89-14 May 90,

Corporate Author:

MASSACHUSETTS UNIV AMHERST

Personal Author(s):

Report Date:

1990-05-30

Pagination or Media Count:

80.0

Abstract:

Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment of leishmaniasis. The objectives of this research are the following 1 To isolate and characterize unique leishmanial enzymes DNA polymerase and S-adenosylsynthetase for the purpose of chemotherapeutic exploitation and 2 To test promising analogs both in vivo and in vitro to determine their potential as antileishmanial agents.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE