The Effects of Single Pulse and Repetitive (Cumulative) Neodymium and Frequency-Doubled Neodymium Laser Irradiations on Prior Light- and Dark-Adapted Monkey Retinas
Final rept. 16 Jun 83-15 Mar 87,
UNIVERSITY OF WESTERN ONTARIO LONDON
Pagination or Media Count:
The project evaluated, morphologically, mainly by electron microscopy, the changes effected one hour and 24 hours post-exposure in Macaca mulatta old animals and M.fascicularis young animals, and up to 25 days in rabbits by a Q-switched pulsed neodymium-YAG laser. An ophthalmologist prior- examined all eyes. The laser burns were inserted in deeply anaesthetized animals, in the macula mainly of the monkeys and just below the visual streak in the rabbits, in light-adapted and dark-adapted conditions and in the morning and afternoon. Each lesion affects a distinctly circumscribed group of cells in the RPE and associated outer segments OS. There is a gradation of damage within a lesion from the most severe centrally to the least severe peripherally.
- Medicine and Medical Research