Accession Number:

ADA238717

Title:

The Effects of Single Pulse and Repetitive (Cumulative) Neodymium and Frequency-Doubled Neodymium Laser Irradiations on Prior Light- and Dark-Adapted Monkey Retinas

Descriptive Note:

Final rept. 16 Jun 83-15 Mar 87,

Corporate Author:

UNIVERSITY OF WESTERN ONTARIO LONDON

Personal Author(s):

Report Date:

1990-12-01

Pagination or Media Count:

191.0

Abstract:

The project evaluated, morphologically, mainly by electron microscopy, the changes effected one hour and 24 hours post-exposure in Macaca mulatta old animals and M.fascicularis young animals, and up to 25 days in rabbits by a Q-switched pulsed neodymium-YAG laser. An ophthalmologist prior- examined all eyes. The laser burns were inserted in deeply anaesthetized animals, in the macula mainly of the monkeys and just below the visual streak in the rabbits, in light-adapted and dark-adapted conditions and in the morning and afternoon. Each lesion affects a distinctly circumscribed group of cells in the RPE and associated outer segments OS. There is a gradation of damage within a lesion from the most severe centrally to the least severe peripherally.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE