Accession Number:

ADA238594

Title:

Models of Excitation-Secretion Coupling in Pituitary Cells

Descriptive Note:

Final rept.

Corporate Author:

DUKE UNIV MEDICAL CENTER DURHAM NC

Personal Author(s):

Report Date:

1991-06-26

Pagination or Media Count:

15.0

Abstract:

This report describes final studies in developing a biophysical description of the electrical events surrounding hormone release in pituitary cells. Utilizing a model based on a membrane capacitance shunted by potassium and calcium channels, we are developing a computer program that will simulate the dynamic response of the transmembrane potential of GH3 cells in response to thyrotropia-releasing hormone TRH. When available, we are using published channel models of potassium and calcium channels. In parallel, we are presuing a phase-plane description of the electrical properties. These models and analyses will be used to investigate effect of temperature on membrane action potentials.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE