Accession Number:

ADA238552

Title:

The Screening and Evaluation of Experimental Antiparasitic Drugs

Descriptive Note:

Annual rept. 1 Feb 1987-31 Jan 1988

Corporate Author:

MIAMI UNIV FL CENTER FOR TROPICAL PARASITIC DISEASES

Personal Author(s):

Report Date:

1990-03-01

Pagination or Media Count:

54.0

Abstract:

Malaria chemotherapeutic studies included a primary antimalarial blood schizontocidal test system MM test, where 1,500 compounds were evaluated against Plasmodium berghei with 327 exhibiting activity, and a secondary antimalarial program consisting of in depth evaluation of compounds against drug-sensitive and drug-resistant lines. In a 3-dose modified MM test artelinic acid exhibited better activity than 5 analogs of artemisinin and only 2 of the 4 different 5-fluoropyrimidine analogs were active. Neither verapamil, diltiazem, nor prochloroperazine reversed chloroquine resistance in a highly chloroquine- resistant line even when mice were pretreated with phenylhydrazine. The antimalarial activity of primaquine, dapsone, and menocotone was hindered when mice received phenylhydrazine. Alloxan did not influence the antimalarial activity of several compounds. FeSO4 but not CuSO4 enhanced the activity of WR181023. Peroxidized cod-liver oil and menhaden oil had antimalarial activity.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE