Accession Number:

ADA238431

Title:

Freeze-Dried Human Red Blood Cells

Descriptive Note:

Progress rept.

Corporate Author:

CRYOPHARM PASADENA CA

Personal Author(s):

Report Date:

1991-07-12

Pagination or Media Count:

64.0

Abstract:

This research report focuses on Cryopharms second clinical study, and summarizes our progress on lyophilized human red blood cells since the last progress report submitted on March 15, 1991. In the second study, low doses 10- 15 ml of packed 51Cr-labeled autologous red cells were infused into four normal volunteers following lyophilization and rehydration of the cells. The design of the clinical study protocol followed accepted procedures for red cell sequestration studies to evaluate splenic function or to diagnose hemolytic anemias. In all four volunteers no changes in vital signs occurred after infusion of the autologous lyophilized red cells, and no associated adverse side effects were observed during the study, through the final follow-up examination conducted one week post-infusion. In all four volunteers, peripheral blood samples were collected for up to five days post-infusion to measure the level of circulating 51Cr. Urine collections during the first 24 hours post-infusion were also counted to measure the level of chromium clearance via the kidneys.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE