Performance Report on Grant N00014-90-J-1648 (City of Hope National Medical Center, Duarte, California)
Rept. no. 2,
CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
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Research efforts during the past four months of this project have been concentrated in two areas 1 testing of tripolyphosphate as a possible agent useful in optimizing the oxygen binding affinities of hemoglobin contained in liposome-encapsulated hemoglobin LEH and 2 the synthesis of LR16. As described in previous reports, the LR16 agents that we initially proposed to use to optimize the oxygen binding properties of LEH is capable of diffusing out of liposomes. The end result of this diffusion process is a less than optimal P50 value and physiological performance for the preparation. Through discussions with Dr. Enrico Bucci, Department of Biological Chemistry, University of Maryland School of Medicine, a well recognized expert in the area of hemoglobin structure and function, the notion emerged that tripolyphosphate may be useful hemoglobin effector molecule to employ in our studies.
- Medicine and Medical Research