Accession Number:

ADA238401

Title:

Metabolism, Seizures, and Blood Flow in Brain Following Organophosphate Exposure: Mechanisms of Action and Possible Therapeutic Agents

Descriptive Note:

Final summary rept. 21 Oct 1985-20 Jul 1990

Corporate Author:

MINNESOTA UNIV DULUTH DEPT OF BIOCHEMISTRY

Personal Author(s):

Report Date:

1991-01-31

Pagination or Media Count:

117.0

Abstract:

Organophosphate OP compounds comprise a major class of chemicals used as insecticides, primarily by agricultural workers and in chemical warfare. These compounds are highly toxic, and an accidental overdose can result in confusion, loss of reflexes, seizure, coma, and ultimately, death 1. The development of effective prophylactic or therapeutic intervention methods requires the thorough understanding of the mechanisms of action and the sequential events leading to the pathophysiological state. Because OP compounds are potent cholinesterace inhibitors most previous work has focused on their actions at the neuromuscular junctions. In recent years, evidence has been growing to suggest that OP toxicity is not exclusively the result of inhibition of acetylcholinesterase, but also of a number of pathophysiological alterations occurring in the central nervous system. In this report, we present studies using the isolated canine brain perfused at constant pressure to allow cerebral blood circulation to vary freely in response to changes in vascular resistance. These studies are the conclusion of a research project designed to examine the effects of OP exposure on brain metabolism and blood flow with the goals of understanding the underlying mechanisms of OP intoxication and suggesting means of therapy.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research
  • Chemical, Biological and Radiological Warfare
  • Pesticides Pollution and Control

Distribution Statement:

APPROVED FOR PUBLIC RELEASE