Accession Number:

ADA238250

Title:

LPI845 Liquid Gun Propellant Dermal Toxicity Studies. An Assessment of the LP1846 Utilizing the Mammalian Cell Cytogenetics Assay With Chinese Hamster Ovary (CHO) Cells

Descriptive Note:

Final rept.

Corporate Author:

SRI INTERNATIONAL MENLO PARK CA

Personal Author(s):

Report Date:

1990-02-01

Pagination or Media Count:

29.0

Abstract:

SRI International assessed the ability of LP1846 to induce chromosomal aberrations CA in Chinese hamster ovary CHO cells both in the presence and absence of rat S-9 metabolic activation enzymes MA. In the definitive studies in the absence of MA, CHO cells exposed to LP1846 at concentrations of 62.5, 125.0 and 250.0 microgramml with an 8- to 10-hour harvest were evaluated microscopically for mitotic indices and for chromosomal aberrations. In the presence of MA, CHO cels exposed to LP1846 concentrations of 625.0, 1250.0, and 2500.0 microgramml with an 8- to 10-hour harvest were evaluated microscopically for mitotic indices and for chromosomal aberrations. Vehicle and positive controls were included in the study. On this basis of our criteria for interpretation, we conclude that LP1846 induces chromosomal aberrations in the presence bt not in the absence of MA under the conditions used in this study.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE