Accession Number:

ADA238228

Title:

Effects of Pharmacologic Intervention on Oxygenation, Lung Water and Protein Leak in the Pseudomonas ARDS Porcine Model

Descriptive Note:

Annual rept. 1 Jul 88-30 Jun 89,

Corporate Author:

MEDICAL COLL OF VIRGINIA RICHMOND

Report Date:

1989-07-01

Pagination or Media Count:

53.0

Abstract:

A porcine model of Pseudomonas induced acute lung injury was studied. It was demonstrated that circulating neutrophils are primed to produce short and long lived reactive oxygen species at a greater and faster rate after 5 hours of sepsis than at baseline. These findings were supported by complimentary in vitro studies. Static and dynamic lung compliance was significantly reduced in septic animals compared with controls. These changes were significantly attenuated by pretreatment with ibuprofen as was the priming of the neutrophil respiratory burst.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE