Effects of Pharmacologic Intervention on Oxygenation, Lung Water and Protein Leak in the Pseudomonas ARDS Porcine Model
Annual rept. 1 Jul 88-30 Jun 89,
MEDICAL COLL OF VIRGINIA RICHMOND
Pagination or Media Count:
A porcine model of Pseudomonas induced acute lung injury was studied. It was demonstrated that circulating neutrophils are primed to produce short and long lived reactive oxygen species at a greater and faster rate after 5 hours of sepsis than at baseline. These findings were supported by complimentary in vitro studies. Static and dynamic lung compliance was significantly reduced in septic animals compared with controls. These changes were significantly attenuated by pretreatment with ibuprofen as was the priming of the neutrophil respiratory burst.
- Medicine and Medical Research