Variation of TFAA in Liver Cells After an Inhalation of Halothane
ARMY BIOMEDICAL RESEARCH AND DEVELOPMENT LAB FORT DETRICK MD
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Trifluoroacetic acid TFAA which is the final metabolic substance of halothane, is discharged in urine. Its peak is around 10 hours after inhalation of halothane. The mechanism of this retardation of discharge may be attributed to the circulation of TFAA in intestines and the liver or to metabolism of halothane deposited on fatty tissues after inhalation of halothane. We previously discussed the possibility of the former. In the present work, we performed the experiment which examined the possibility of the latter.
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