Accession Number:

ADA238225

Title:

Variation of TFAA in Liver Cells After an Inhalation of Halothane

Descriptive Note:

Journal article

Corporate Author:

ARMY BIOMEDICAL RESEARCH AND DEVELOPMENT LAB FORT DETRICK MD

Personal Author(s):

• Arai, K.
• Fujii, H.
• Morio, M.
• Nakao, M.
• Shiraishi, M.

Report Date:

1991-01-01

Pagination or Media Count:

4.0

Abstract:

Trifluoroacetic acid TFAA which is the final metabolic substance of halothane, is discharged in urine. Its peak is around 10 hours after inhalation of halothane. The mechanism of this retardation of discharge may be attributed to the circulation of TFAA in intestines and the liver or to metabolism of halothane deposited on fatty tissues after inhalation of halothane. We previously discussed the possibility of the former. In the present work, we performed the experiment which examined the possibility of the latter.

Descriptors:

• *LIVER
• *FLUORINE
• *ACETIC ACID
• TRANSLATIONS
• FATS
• HALOGENATED HYDROCARBONS
• ETHANES
• INTESTINES
• URINE
• RETARDATION
• INHALATION
• JAPAN
• METABOLISM
• TISSUES(BIOLOGY)
• CELLS

Subject Categories:

• Commercial and General Aviation
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE