Genetics and Metabolism of Solventogenic and Cellulolytic Clostridia
Final technical rept.,
NEW HAMPSHIRE UNIV DURHAM
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1 Metabolic differentiation to solventogenesis with slowing growth rate is sequential rather than simultaneous in Clostridium beijerinckii, with the production of butanol occurring in stage III of sporulation. 2 A pathway to n-propanol rather than to 2-propanol appears in this species at very slow growth under carbon limitation. 3 A constant fraction of carbon-energy substrate is used by Clostridium strain C7 for cellulase secretion at any growth rate exoenzyme production is independent of maintenance energy costs and can therefore be produced efficiently at any growth rate. 4 Transformation in Bacillus subtilis occurs with maximum frequency at a doubling time of 2-3 hours, a region in which the cell is switching from anabolic to catabolic limitation.
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